新冠新药千金藤素是什么?

9个月前 (05-13) 0 点赞 0 收藏 0 评论 362 已阅读
5月13日,《科技日报》报道称,中国科学家发现了一款强效抑制新冠病毒的药物

北京化工大学官微发布文章:5月10日,童贻刚教授团队发现千金藤素获得国家发明专利。专利说明显示, 10uM(微摩尔/升)的千金藤素抑制冠状病毒复制的倍数为15393倍。

“15393倍”的含义,童贻刚在接受采访时做出了解释:“通俗来讲,如果有15393个病毒,在用10uM千金藤素药物后,病毒数将只有1个。”

千金藤素是一款老牌中成药,国家药监局数据库显示:国内获批的千金藤素制剂都是片剂,共4个批件。千金藤素能治新冠的消息一经放出,股市迅速反应,5月13日有批件的大理药业涨停,云南白药上涨8.66%。

吊诡的是,和千金藤素完全没关系的千金药业也迎来涨停,只因为起了个好名字。

继以岭药业的连花清瘟之后,新冒头的千金藤素能否成为中药抗疫的中坚力量?

新冠新药千金藤素是什么?

病毒模型和体外试验的双重成果

千金藤素是中药千金藤的活性化学成份,已有40多年的临床应用历史,常用于因肿瘤化疗放疗引起的粒细胞缺乏症,或其他原因引起的白细胞减少症。

新冠疫情爆发以来,科学家研究千金藤素其实已有一段时间。

据北京化工大学生命科学与技术学院官网,2020年3月,因研究新冠病毒的实验室要求较高,童贻刚团队从穿山甲身上分离出一种冠状病毒作为研究对象,“它与新冠病毒的亲缘关系大大优于SARS病毒,是理想的抗新冠病毒药物筛选模型。”

针对这种冠状病毒进行了研究之后,童贻刚团队在2020年5月在《中华医学杂志》英文版发布了论文,披露了相关抗新冠药物的研究结果:将穿山甲冠状病毒与2406种临床批准药物相比后,发现千金藤素、塞拉菌素和盐酸甲氟喹是治疗新型冠状病毒感染的潜在药物。

新冠新药千金藤素是什么?

但当时包括双黄连、板蓝根等中成药都在开展治疗新冠的实验,千金藤素的价值并未被广泛关注。

童贻刚团队并未放弃,一直在努力弄清楚千金藤素是如何发挥作用的。2021年11月,童贻刚团队在《BRIEFINGS IN BIOINFORMATICS》上发表论文,公示了千金藤素治疗新冠的作用路径:通过有效逆转感染细胞中大多数失调的基因和途径,包括ER应激/未折叠蛋白反应和HSF1介导的热休克反应等发挥作用。

新冠新药千金藤素是什么?

但以上实验都是体外细胞层面,并未涉及人体试验。

新冠新药千金藤素是什么?

优于瑞德西韦,即将开启临床

就在国内外新冠口服药你争我夺的时候,千金藤素的出现仿佛一股清流。

5月10日,童贻刚团队获得一项发明专利证书,使2年多以来千金藤素的相关研究露出水面。

新冠新药千金藤素是什么?

图源于北京化工大学官微

除了前面提到的“15393倍”这个惊艳的数字之外,北京化工大学还在官微中指出:美国学者曾在《科学》发表论文证实,千金藤素的数据优于瑞德西韦和帕罗韦德。另外,日本国立传染病研究所所长胁田隆字团队以及其他团队也曾证实过,千金藤素有抗新冠病毒的效果。

不过,暂未查询到相关论文。

仔细研读专利说明文字,千金藤素对SARS-CoV的抑制实际上是低效抑制,并不能说明其能强有效地抑制xCoV和SARS-CoV-2。其中,xCoV指的就是穿山甲身上提取的冠状病毒,SARS-CoV-2则是我们常说的新冠病毒。据发明人表示,两种病毒的蛋白同源性达92.5%。

我们注意到,在国家专利局官网上,童贻刚参与获得的除了上述专利之外,还有一个《一种千金藤素吸入药剂和制剂极其制备方法与应用》的专利,相关说明显示:该吸入药剂可通过吸入的给药方式用于预防和/或治疗新型冠状病毒,其生物利用度高、快速释药、快速起效。

获批新专利或许意味着千金藤素治疗新冠将成为现实。北京化工大学官微称,已有一家加拿大药企与美国FDA接洽,预计今年下半年启动千金藤素治疗新冠的临床试验。

千金藤素无疑给中药抗疫带来新的选择。目前国内有千金藤素制剂的4家企业,分别是沈阳管城制药、云南白药集团文山七花公司、云南白药集团大理药业、云南生物谷药业,均为中药类批件。另外,南宁百会药业拥有一个“千金藤啶碱片”的化药批件。

不论临床试验结果如何,千金藤素的好消息至少说明中药治疗新冠的努力一直没有停步。

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千金藤茶代茶饮代用素片青草养生茶小青藤官方正品旗舰店大药房-F 券后价¥56 天猫 优惠券¥3 立即领券
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flowflex新冠病毒抗原检测试剂盒快速家庭自测盒自检核酸试纸JY 券后价¥31.00 天猫 优惠券¥5.00 立即领券
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